/* ── Reset & Variables ───────────────────────────────────────────────────── */
*, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }

:root {
  --bg:        #0d1117;
  --surface:   #161b22;
  --surface2:  #1c2333;
  --border:    #30363d;
  --border2:   #21262d;
  --text:      #e6edf3;
  --text-sub:  #8b949e;
  --accent:    #1f6feb;
  --accent-h:  #388bfd;
  --success:   #3fb950;
  --warning:   #d29922;
  --danger:    #f85149;
  --teal:      #39d353;
  --purple:    #bc8cff;
  --tag-bg:    #1f2937;
  --radius:    8px;
  --radius-lg: 14px;
  --shadow:    0 4px 24px rgba(0,0,0,.4);
  --font:      -apple-system, BlinkMacSystemFont, 'Segoe UI', 'Inter', sans-serif;
  --mono:      'JetBrains Mono', 'Fira Code', 'Courier New', monospace;
}

html { scroll-behavior: smooth; }

body {
  background: var(--bg);
  color: var(--text);
  font-family: var(--font);
  font-size: 14px;
  line-height: 1.6;
  min-height: 100vh;
}

/* ── Header ─────────────────────────────────────────────────────────────── */
.header {
  position: sticky; top: 0; z-index: 100;
  display: flex; align-items: center; justify-content: space-between;
  padding: 0 24px;
  height: 56px;
  background: var(--surface);
  border-bottom: 1px solid var(--border);
  backdrop-filter: blur(8px);
}

.header-brand {
  display: flex; align-items: center; gap: 10px;
  cursor: pointer;
  text-decoration: none;
}
.header-icon { width: 22px; height: 22px; color: var(--accent-h); }
.header-title {
  font-size: 16px; font-weight: 700;
  background: linear-gradient(90deg, #58a6ff, #39d353);
  -webkit-background-clip: text; -webkit-text-fill-color: transparent;
  letter-spacing: -.3px;
}

.header-nav { display: flex; gap: 4px; }
.nav-btn {
  background: transparent; border: none; color: var(--text-sub);
  padding: 6px 14px; border-radius: var(--radius); cursor: pointer;
  font-size: 13px; font-weight: 500; transition: all .15s;
}
.nav-btn:hover, .nav-btn.active { background: var(--surface2); color: var(--text); }

/* ── Main ────────────────────────────────────────────────────────────────── */
#app { max-width: 1200px; margin: 0 auto; padding: 32px 24px 80px; }

/* ── Views ───────────────────────────────────────────────────────────────── */
.view { animation: fadeIn .2s ease; }
@keyframes fadeIn { from { opacity: 0; transform: translateY(6px); } to { opacity: 1; transform: translateY(0); } }

.view-header {
  display: flex; align-items: center; justify-content: space-between;
  margin-bottom: 28px; flex-wrap: wrap; gap: 12px;
}
.view-title { font-size: 24px; font-weight: 700; letter-spacing: -.4px; }
.view-sub { color: var(--text-sub); font-size: 13px; margin-top: 2px; }

/* ── Buttons ─────────────────────────────────────────────────────────────── */
.btn {
  display: inline-flex; align-items: center; gap: 6px;
  padding: 8px 16px; border-radius: var(--radius); border: 1px solid transparent;
  font-size: 13px; font-weight: 500; cursor: pointer; transition: all .15s;
  white-space: nowrap; text-decoration: none;
}
.btn-primary  { background: var(--accent);  border-color: var(--accent);  color: #fff; }
.btn-primary:hover  { background: var(--accent-h); border-color: var(--accent-h); }
.btn-secondary { background: var(--surface2); border-color: var(--border); color: var(--text); }
.btn-secondary:hover { background: var(--border); }
.btn-ghost  { background: transparent; border-color: transparent; color: var(--text-sub); }
.btn-ghost:hover { color: var(--text); background: var(--surface2); }
.btn-danger { background: transparent; border-color: var(--danger); color: var(--danger); }
.btn-danger:hover { background: var(--danger); color: #fff; }
.btn:disabled { opacity: .5; cursor: not-allowed; }

/* ── Inputs ──────────────────────────────────────────────────────────────── */
.input {
  width: 100%; padding: 9px 12px;
  background: var(--surface2); border: 1px solid var(--border);
  border-radius: var(--radius); color: var(--text); font-size: 14px;
  font-family: var(--font); transition: border-color .15s;
  outline: none;
}
.input:focus { border-color: var(--accent); box-shadow: 0 0 0 3px rgba(31,111,235,.15); }
.input::placeholder { color: var(--text-sub); }
.textarea { resize: vertical; min-height: 70px; }

select.input option { background: var(--surface2); }

/* ── Search bar ──────────────────────────────────────────────────────────── */
.search-bar-wrap { margin-bottom: 24px; }
.search-input { max-width: 480px; }

.gene-search-bar {
  display: flex; gap: 10px; margin-bottom: 20px; flex-wrap: wrap;
}
.gene-input { flex: 1; min-width: 200px; font-family: var(--mono); font-size: 13px; }

/* ── Patient grid ────────────────────────────────────────────────────────── */
.patients-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(300px, 1fr));
  gap: 16px;
}

.patient-tile {
  background: var(--surface); border: 1px solid var(--border);
  border-radius: var(--radius-lg); padding: 20px;
  cursor: pointer; transition: all .18s;
  position: relative; overflow: hidden;
}
.patient-tile::after {
  content: ''; position: absolute; inset: 0;
  background: linear-gradient(135deg, rgba(56,139,253,.04), transparent);
  opacity: 0; transition: opacity .18s;
}
.patient-tile:hover { border-color: var(--accent); transform: translateY(-2px); box-shadow: var(--shadow); }
.patient-tile:hover::after { opacity: 1; }

.tile-avatar {
  width: 44px; height: 44px; border-radius: 50%;
  background: linear-gradient(135deg, #1f6feb, #39d353);
  display: flex; align-items: center; justify-content: center;
  font-size: 18px; font-weight: 700; color: #fff;
  margin-bottom: 12px;
}
.tile-name { font-size: 16px; font-weight: 600; margin-bottom: 4px; }
.tile-meta { color: var(--text-sub); font-size: 12px; line-height: 1.8; }
.tile-badge {
  display: inline-flex; align-items: center; gap: 4px;
  margin-top: 12px; padding: 3px 10px;
  border-radius: 20px; font-size: 11px; font-weight: 600;
  background: rgba(63,185,80,.1); color: var(--success); border: 1px solid rgba(63,185,80,.2);
}
.tile-badge.no-files { background: rgba(139,148,158,.1); color: var(--text-sub); border-color: var(--border); }
.tile-report-btn {
  display: block; margin-top: 10px;
  padding: 5px 10px; border-radius: var(--radius);
  font-size: 11px; font-weight: 600;
  background: rgba(56,139,253,.1); color: var(--accent);
  border: 1px solid rgba(56,139,253,.2);
  text-decoration: none; text-align: center;
  transition: background .15s;
  position: relative; z-index: 1;
}
.tile-report-btn:hover { background: rgba(56,139,253,.2); }

/* ── Patient card (detail view) ──────────────────────────────────────────── */
.patient-card {
  background: var(--surface); border: 1px solid var(--border);
  border-radius: var(--radius-lg); padding: 28px;
  display: flex; gap: 24px; flex-wrap: wrap;
  margin-bottom: 28px;
}
.patient-card-avatar {
  width: 72px; height: 72px; border-radius: 50%;
  background: linear-gradient(135deg, #1f6feb, #39d353);
  display: flex; align-items: center; justify-content: center;
  font-size: 28px; font-weight: 700; color: #fff;
  flex-shrink: 0;
}
.patient-card-info { flex: 1; min-width: 200px; }
.patient-card-name { font-size: 22px; font-weight: 700; margin-bottom: 6px; }
.patient-card-details {
  display: grid; grid-template-columns: repeat(auto-fill, minmax(180px, 1fr));
  gap: 8px 24px; margin-top: 12px;
}
.detail-item { display: flex; flex-direction: column; }
.detail-label { font-size: 11px; color: var(--text-sub); text-transform: uppercase; letter-spacing: .5px; }
.detail-value { font-size: 14px; font-weight: 500; }

/* ── Section blocks ──────────────────────────────────────────────────────── */
.section-block {
  background: var(--surface); border: 1px solid var(--border);
  border-radius: var(--radius-lg); padding: 24px;
  margin-bottom: 24px;
}
.section-header {
  display: flex; align-items: center; gap: 12px;
  margin-bottom: 8px; flex-wrap: wrap;
}
.section-title { font-size: 17px; font-weight: 600; }
.section-hint  { color: var(--text-sub); font-size: 12px; margin-bottom: 16px; }

/* ── Files list ──────────────────────────────────────────────────────────── */
.files-list { display: flex; flex-direction: column; gap: 10px; margin-top: 12px; }

.file-row {
  display: flex; align-items: center; gap: 14px;
  background: var(--surface2); border: 1px solid var(--border2);
  border-radius: var(--radius); padding: 12px 16px;
}
.file-icon { font-size: 22px; flex-shrink: 0; }
.file-info { flex: 1; min-width: 0; }
.file-name { font-size: 13px; font-weight: 600; white-space: nowrap; overflow: hidden; text-overflow: ellipsis; }
.file-meta { font-size: 11px; color: var(--text-sub); margin-top: 2px; }
.file-status {
  padding: 3px 10px; border-radius: 20px; font-size: 11px; font-weight: 600; flex-shrink: 0;
}
.file-status.ready      { background: rgba(63,185,80,.1); color: var(--success); }
.file-status.processing { background: rgba(210,153,34,.1); color: var(--warning); }
.file-status.error      { background: rgba(248,81,73,.1);  color: var(--danger); }

/* ── Gene results table ──────────────────────────────────────────────────── */
.gene-results-wrap { overflow-x: auto; }

.gene-table {
  width: 100%; border-collapse: collapse;
  font-size: 13px; min-width: 640px;
}
.gene-table th {
  text-align: left; padding: 10px 14px;
  background: var(--surface2); color: var(--text-sub);
  font-size: 11px; text-transform: uppercase; letter-spacing: .5px;
  border-bottom: 1px solid var(--border);
  position: sticky; top: 0; z-index: 1;
}
.gene-table td {
  padding: 10px 14px;
  border-bottom: 1px solid var(--border2);
  vertical-align: middle;
}
.gene-table tbody tr:hover { background: var(--surface2); cursor: pointer; }
.gene-table tbody tr:last-child td { border-bottom: none; }

.rsid-cell {
  font-family: var(--mono); font-size: 12px; color: var(--accent-h);
  text-decoration: underline; text-underline-offset: 3px;
}
.genotype-badge {
  font-family: var(--mono); font-size: 12px; font-weight: 700;
  padding: 2px 8px; border-radius: 4px;
  background: var(--tag-bg); border: 1px solid var(--border);
}
.clinsig { padding: 2px 8px; border-radius: 4px; font-size: 11px; font-weight: 600; }
.clinsig.benign   { background: rgba(63,185,80,.1); color: var(--success); }
.clinsig.pathogenic { background: rgba(248,81,73,.1); color: var(--danger); }
.clinsig.uncertain { background: rgba(210,153,34,.1); color: var(--warning); }
.clinsig.other    { background: var(--tag-bg); color: var(--text-sub); }

.gene-name-cell { font-weight: 600; color: var(--purple); }
.chrom-cell { font-family: var(--mono); font-size: 12px; }
.pos-cell   { font-family: var(--mono); font-size: 12px; color: var(--text-sub); }

.no-results {
  text-align: center; padding: 48px 24px; color: var(--text-sub);
}
.no-results .no-icon { font-size: 40px; margin-bottom: 12px; }
.no-results p { font-size: 14px; }

/* Pagination row */
.pagination { display: flex; align-items: center; gap: 10px; padding: 16px 0; justify-content: center; }
.page-info { color: var(--text-sub); font-size: 12px; }

/* ── Modal ───────────────────────────────────────────────────────────────── */
.modal-overlay {
  display: none; position: fixed; inset: 0; z-index: 200;
  background: rgba(0,0,0,.65); backdrop-filter: blur(4px);
  align-items: center; justify-content: center; padding: 20px;
}
.modal-overlay.open { display: flex; }

.modal {
  background: var(--surface); border: 1px solid var(--border);
  border-radius: var(--radius-lg); width: 100%; max-width: 560px;
  box-shadow: var(--shadow); animation: modalIn .2s ease;
}
@keyframes modalIn { from { opacity: 0; transform: scale(.95); } to { opacity: 1; transform: scale(1); } }

.modal-header {
  display: flex; align-items: center; justify-content: space-between;
  padding: 20px 24px 0;
}
.modal-title { font-size: 18px; font-weight: 700; }
.modal-close {
  background: none; border: none; color: var(--text-sub); font-size: 18px;
  cursor: pointer; padding: 4px; border-radius: 4px; transition: color .15s;
}
.modal-close:hover { color: var(--text); }

form#patient-form { padding: 20px 24px 24px; }

.form-row { display: grid; grid-template-columns: 1fr 1fr; gap: 14px; margin-bottom: 14px; }
@media (max-width: 480px) { .form-row { grid-template-columns: 1fr; } }

.form-group { display: flex; flex-direction: column; gap: 5px; margin-bottom: 14px; }
.label { font-size: 12px; font-weight: 600; color: var(--text-sub); text-transform: uppercase; letter-spacing: .4px; }

.modal-footer {
  display: flex; gap: 10px; justify-content: flex-end;
  padding-top: 8px; border-top: 1px solid var(--border); margin-top: 8px;
}

/* ── Drawer (SNP detail) ─────────────────────────────────────────────────── */
.drawer-overlay {
  display: none; position: fixed; inset: 0; z-index: 200;
  background: rgba(0,0,0,.5);
}
.drawer-overlay.open { display: block; }

.drawer {
  position: fixed; right: 0; top: 0; bottom: 0; z-index: 201;
  width: min(420px, 92vw);
  background: var(--surface); border-left: 1px solid var(--border);
  box-shadow: -8px 0 40px rgba(0,0,0,.4);
  display: flex; flex-direction: column;
  animation: slideIn .22s ease;
}
@keyframes slideIn { from { transform: translateX(100%); } to { transform: translateX(0); } }

.drawer-header {
  display: flex; align-items: center; justify-content: space-between;
  padding: 20px 24px; border-bottom: 1px solid var(--border); flex-shrink: 0;
}
.drawer-title { font-size: 17px; font-weight: 700; font-family: var(--mono); color: var(--accent-h); }

.drawer-content { padding: 24px; overflow-y: auto; flex: 1; }

.detail-section { margin-bottom: 20px; }
.detail-section-title {
  font-size: 11px; font-weight: 700; text-transform: uppercase;
  letter-spacing: .8px; color: var(--text-sub); margin-bottom: 10px;
}
.detail-row { display: flex; flex-direction: column; gap: 2px; margin-bottom: 12px; }
.detail-key { font-size: 11px; color: var(--text-sub); text-transform: uppercase; letter-spacing: .4px; }
.detail-val { font-size: 14px; font-weight: 500; word-break: break-word; }
.detail-val.mono { font-family: var(--mono); font-size: 13px; }

/* ── Toast ───────────────────────────────────────────────────────────────── */
.toast {
  position: fixed; bottom: 24px; right: 24px; z-index: 500;
  padding: 12px 20px; border-radius: var(--radius); font-size: 13px; font-weight: 500;
  background: var(--surface2); border: 1px solid var(--border);
  box-shadow: var(--shadow); color: var(--text);
  opacity: 0; transform: translateY(10px); pointer-events: none;
  transition: all .22s ease; max-width: 360px;
}
.toast.show { opacity: 1; transform: translateY(0); }
.toast.success { border-color: var(--success); color: var(--success); }
.toast.error   { border-color: var(--danger);  color: var(--danger); }

/* ── Loading states ──────────────────────────────────────────────────────── */
.spinner {
  width: 28px; height: 28px; margin: 40px auto; display: block;
  border: 3px solid var(--border); border-top-color: var(--accent);
  border-radius: 50%; animation: spin .7s linear infinite;
}
@keyframes spin { to { transform: rotate(360deg); } }

.skeleton { height: 90px; background: var(--surface); border-radius: var(--radius-lg); animation: pulse 1.5s ease infinite; }
.skeleton-list { display: flex; flex-direction: column; gap: 12px; }
@keyframes pulse { 0%, 100% { opacity: 1; } 50% { opacity: .4; } }

/* ── Banner de resultado NCBI ────────────────────────────────────────────── */
.gene-banner {
  display: flex; align-items: center; gap: 10px;
  padding: 12px 16px; border-radius: var(--radius);
  font-size: 13px; margin-bottom: 14px; border: 1px solid;
}
.gene-banner.info {
  background: rgba(31,111,235,.08); border-color: rgba(31,111,235,.3); color: #58a6ff;
}
.gene-banner.warn {
  background: rgba(210,153,34,.08); border-color: rgba(210,153,34,.3); color: var(--warning);
}

/* ── Upload progress indicator ───────────────────────────────────────────── */
.upload-progress {
  background: var(--surface2); border: 1px dashed var(--accent);
  border-radius: var(--radius); padding: 16px; color: var(--text-sub);
  font-size: 13px; display: flex; align-items: center; gap: 12px;
}
.upload-progress .spinner { width: 18px; height: 18px; margin: 0; flex-shrink: 0; }

/* ── Responsive ──────────────────────────────────────────────────────────── */
@media (max-width: 600px) {
  #app { padding: 20px 14px 60px; }
  .patient-card { flex-direction: column; }
  .header { padding: 0 14px; }
  .gene-search-bar .btn { width: 100%; justify-content: center; }
}

/* ── Back button ─────────────────────────────────────────────────────────── */
.back-btn { margin-left: -8px; }
.patient-header-actions { display: flex; gap: 8px; }

/* ── Empty state ─────────────────────────────────────────────────────────── */
.empty-state {
  text-align: center; padding: 64px 24px;
  color: var(--text-sub);
}
.empty-state .empty-icon { font-size: 48px; margin-bottom: 16px; }
.empty-state h3 { font-size: 18px; font-weight: 600; color: var(--text); margin-bottom: 8px; }
.empty-state p { font-size: 14px; margin-bottom: 24px; }

/* ── Pathway Map Overlay ─────────────────────────────────────────────────── */
.pathway-overlay {
  display: none;
  position: fixed; inset: 0; z-index: 300;
  background: rgba(0,0,0,.75);
  backdrop-filter: blur(4px);
}
.pathway-overlay.open { display: flex; align-items: flex-start; justify-content: center; }

.pathway-panel {
  display: flex; flex-direction: column;
  width: 96vw; height: 96vh;
  margin-top: 2vh;
  background: var(--surface); border: 1px solid var(--border);
  border-radius: var(--radius-lg); overflow: hidden;
  box-shadow: var(--shadow);
  animation: modalIn .2s ease;
}

.pathway-toolbar {
  display: flex; align-items: center; justify-content: space-between;
  padding: 12px 20px; border-bottom: 1px solid var(--border);
  flex-shrink: 0; gap: 12px;
}
.pathway-toolbar-title {
  font-size: 16px; font-weight: 700; letter-spacing: -.3px;
}
.pathway-toolbar-actions { display: flex; gap: 8px; align-items: center; }
.pathway-zoom-btn { padding: 6px 12px; font-size: 16px; font-weight: 700; line-height: 1; }

.pathway-legend {
  display: flex; flex-wrap: wrap; gap: 8px 20px;
  padding: 10px 20px; border-bottom: 1px solid var(--border);
  flex-shrink: 0;
}
.legend-item {
  display: flex; align-items: center; gap: 6px;
  font-size: 12px; color: var(--text-sub);
}
.legend-dot {
  width: 12px; height: 12px; border-radius: 3px; flex-shrink: 0;
}
.legend-green  { background: #00802f; }
.legend-yellow { background: #ffff00; }
.legend-red    { background: #cc0000; }
.legend-white  { background: #ffffff; border: 1px solid #ccc; }

.pathway-scroll-area {
  flex: 1; overflow: auto;
  display: flex; align-items: flex-start; justify-content: flex-start;
  padding: 16px;
  scroll-behavior: smooth;
}
.pathway-map-container {
  position: relative; flex-shrink: 0;
  transform-origin: top left;
  min-width: fit-content;
  min-height: fit-content;
}
.pathway-genes-layer {
  position: absolute; inset: 0; pointer-events: none;
}
.pathway-loading {
  position: absolute; inset: 0;
  display: flex; align-items: center; justify-content: center;
  background: rgba(13,17,23,.6);
}

/* ── Pathway map image container ─────────────────────────────────────────── */
#pathway-svg-host {
  display: flex; align-items: flex-start; justify-content: flex-start;
  position: relative;
}
#pathway-svg-host img {
  display: block;
  width: auto;
  height: auto;
  max-width: none;
  user-select: none;
}

/* ── Print: pathway map ──────────────────────────────────────────────────── */
@media print {
  body > *:not(#pathway-overlay) { display: none !important; }
  .pathway-overlay { display: block !important; position: static !important; background: none !important; }
  .pathway-panel   { width: 100% !important; height: auto !important; margin: 0 !important;
                     box-shadow: none !important; border: none !important; }
  .pathway-toolbar-actions { display: none !important; }
  .pathway-scroll-area { overflow: visible !important; padding: 0 !important; }
  .pathway-map-container { transform: none !important; }
  .gene-box { opacity: 1 !important; print-color-adjust: exact; -webkit-print-color-adjust: exact; }
  .pathway-loading { display: none !important; }
}